Peptide Database

Peptide NameSLAY-screened peptide P2936

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC57H91N19O17S

DescriptionStandard

        PVMVHPRGTTHD
    

Molecular Weight1346.51 Da

Isoelectric Point (pI)7.34

Net Charge (pH 7.0)0.14

Net Charge (pH 7.4) -0.02

Charge Density (pH 7.0) 0.0114

GRAVY Index-0.76

Hydrophobic Moment 0.22

Boman Index-0.07

Instability Index2.38

Aliphatic Index 48.33

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 557.66

LogP -6.21

H-bond Donors 20.0

H-bond Acceptors 20.0

Rotatable Bonds 39.0

Heavy Atoms 94.0

Ring Count 4.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0076057 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/