Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length476 amino acids

Chemical FormulaC2357H3691N583O693S19

DescriptionStandard

        MDFAYRLTLLFSIAAFVGTADAENPGLVVRVTQKGLDYALQEGMIVLQQQLSQIQLPDFSGTYDVGFLGKVEYKFTSMAISSVQLPSFQVSPVPDMGLKLSISGAFIQVDGRWDVRYQFIHEDGSFNVKVMGLSISVGLKLGNDESGRPTIAPTDCSCHISNVEVHMSGTIGWLVDLFHNNVESELRQSMEDQICPEVTQSITSKLLPLLQTLPVTAKIDQISAIDYSLTGPPSVMANWVDVSLKGEFFDISHRTAPPFAPPLLSLPPEQDLMVYFAVSEYLFNTAGLVYQSAGALVFNLTDDMIPKESSVHLNTSSFGLLIPSVSKMYPNMLMKLEISAASAPALNINPGNLTLSPVGNIQAYAILPNSSLAPLFLLQMKMNALAKVAVNSGKIVGSLELGKVEISLVHSDVGLFSVSVISMAVNYYVSATLLPRVNEILKNGFPLPLIDHIQLTDFVIETYEHYLLFGANAHYE
    

Molecular Weight51892.24 Da

Isoelectric Point (pI)4.84

Net Charge (pH 7.0)-18.60

Net Charge (pH 7.4) -19.47

Charge Density (pH 7.0) -0.0391

GRAVY Index0.27

Hydrophobic Moment 0.65

Boman Index0.22

Instability Index42.64

Aliphatic Index 106.66

Aromaticity 0.0882

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40465.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0256133 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis (Western clawed frog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria