Peptide Database

Peptide NameMidkine (MK)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length142 amino acids

Chemical FormulaC679H1114N198O203S12

DescriptionStandard

        MELRAFCVILLITFLAVSSQAAKNKKEKGKKGASDCTEWTWGRCIPNSKDCGAGTREGTCKEETRKLKCKIPCNWKKAFGADCKYKFENWGECNATTGQKVRSGTLKKALYNADCQQTVEATKPCSLKTKSKSKGKKGKGKE
    

Molecular Weight15684.09 Da

Isoelectric Point (pI)9.60

Net Charge (pH 7.0)17.40

Net Charge (pH 7.4) 16.96

Charge Density (pH 7.0) 0.1225

GRAVY Index-0.81

Hydrophobic Moment 0.52

Boman Index-0.21

Instability Index7.35

Aliphatic Index 49.58

Aromaticity 0.0704

Extinction Coeff. Reduced 24980.00

Extinction Coeff. Oxidized 25605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6613.41

LogP -76.19

H-bond Donors 243.0

H-bond Acceptors 233.0

Rotatable Bonds 552.0

Heavy Atoms 1092.0

Ring Count 17.0

Amide Bonds 151.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0202847 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyPleiotrophin

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetGram-negative and Gram-positive bacteria

RECORD: Rec_0320986 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyMidkine

Structure & Mods

ConfigLinear cysteine-rich peptide scaffold with intramolecular disulfide potential [Linear]

Chiralityunresolved/noncanonical residue assignment [Modified]

Other ModsMature segment delimiter unresolved in source JSON; precursor sequence retained

Bio-Activity Profile

Function

-