Peptide Database

Peptide NameSLAY-screened peptide P3154

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC86H127N21O22S3

DescriptionStandard

        CGPSYRTLPLFVAWCCS
    

Molecular Weight1903.25 Da

Isoelectric Point (pI)7.96

Net Charge (pH 7.0)0.73

Net Charge (pH 7.4) 0.48

Charge Density (pH 7.0) 0.0429

GRAVY Index0.66

Hydrophobic Moment 0.34

Boman Index0.28

Instability Index22.12

Aliphatic Index 68.82

Aromaticity 0.1765

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 669.95

LogP -5.10

H-bond Donors 27.0

H-bond Acceptors 26.0

Rotatable Bonds 52.0

Heavy Atoms 132.0

Ring Count 6.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425725 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/