Peptide Database

Peptide NameDesmoteplase

Function Ontology

Hemostasis ▸ Anticoagulant activity

Hemostasis ▸ Fibrinolytic activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length477 amino acids

Chemical FormulaC2338H3629N673O702S38

DescriptionStandard

        MVNTMKTKLLCVLLLCGAVFSLPRQETYRQLARGSRAYGVACKDEITQMTYRRQESWLRPEVRSKRVEHCQCDRGQARCHTVPVNSCSEPRCFNGGTCWQAVYFSDFVCQCPAGYTGKRCEVDTRATCYEGQGVTYRGTWSTAESRVECINWNSSLLTRRTYNGRMPDAFNLGLGNHNYCRNPNGAPKPWCYVIKAGKFTSESCSVPVCSKATCGLRKYKEPQLHSTGGLFTDITSHPWQAAIFAQNRRSSGERFLCGGILISSCWVLTAAHCFQESYLPDQLKVVLGRTYRVKPGEEEQTFKVKKYIVHKEFDDDTYNNDIALLQLKSDSPQCAQESDSVRAICLPEANLQLPDWTECELSGYGKHKSSSPFYSEQLKEGHVRLYPSSRCAPKFLFNKTVTNNMLCAGDTRSGEIYPNVHDACQGDSGGPLVCMNDNHMTLLGIISWGVGCGEKDVPGVYTKVTNYLGWIRDNMHL
    

Molecular Weight53615.38 Da

Isoelectric Point (pI)8.53

Net Charge (pH 7.0)10.30

Net Charge (pH 7.4) 8.91

Charge Density (pH 7.0) 0.0216

GRAVY Index-0.46

Hydrophobic Moment 0.78

Boman Index-0.06

Instability Index45.21

Aliphatic Index 65.79

Aromaticity 0.0964

Extinction Coeff. Reduced 86290.00

Extinction Coeff. Oxidized 88165.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0017356 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyEnzyme

Tax ID32630

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme replacement Thrombolytic Fibrinolytic

RECORD: Rec_0145987 VERIFIED: NO