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MYP_080428
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Basic Information
Ocellatin-P1 (Pentadactylin)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C112H200N30O34S
Standard
Sequence
GLLDTLKGAAKNVVGSLASKVMEKL
Physicochemical Analysis
2543.03 Da
9.53
1.76
1.55
0.0704
0.37
0.53
0.15
-16.79
124.80
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1044.18
-9.96
36.0
37.0
91.0
177.0
0.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0316337 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pentadactylus [Animal]
Frog skin active peptide (FSAP); Ocellatin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Hemolytic
Staphylococcus aureus
PMID16236555 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16236555/
RECORD: Rec_0318159 VERIFIED: YES
Provenance & Taxonomy
American bullfrog [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Staphylococcus epidermidis RP62A
100 μM
MIC
PaperPentadactylin: an antimicrobial peptide from the skin secretions of the South American bullfrog Leptodactylus pentadactylus
RECORD: Rec_0319109 VERIFIED: YES
Provenance & Taxonomy
American bullfrog [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Enterobacter cloacae HNTCC 53001
50 μM
MIC
PaperPentadactylin: an antimicrobial peptide from the skin secretions of the South American bullfrog Leptodactylus pentadactylus
RECORD: Rec_0324127 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0355770 VERIFIED: YES
Provenance & Taxonomy
American bullfrog [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Anticancer: killed the murine melanoma cell line B16F10
25.7 μM
IC50
PaperPentadactylin: an antimicrobial peptide from the skin secretions of the South American bullfrog Leptodactylus pentadactylus
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