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MYP_080328
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Basic Information
LL-37 KR-12 [Q5K,D9K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C74H137N25O13
Standard
Sequence
KRIVKRIKKFLR
Physicochemical Analysis
1585.04 Da
12.00
6.76
6.55
0.5630
-0.78
1.07
-0.62
63.00
121.67
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
673.20
-2.93
26.0
20.0
60.0
112.0
1.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015997 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa ATCC 27853
1.25 μM
MIC
PMID29430821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29430821/
RECORD: Rec_0017140 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus
PaperBackbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability.
RECORD: Rec_0148143 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 29213
2.5 μM
MIC
PMID29430821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29430821/
RECORD: Rec_0171748 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
100 μM
Hemolysis
PMID29430821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29430821/
RECORD: Rec_0177588 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
2.5 μM
MIC
PMID29430821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29430821/
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