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MYP_080300
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
31 amino acids
C152H239N47O44S6
Standard
Sequence
CFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ
Physicochemical Analysis
3621.20 Da
8.67
2.70
2.40
0.0871
-0.33
0.73
-0.17
47.22
47.10
0.1290
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1506.17
-17.22
60.0
53.0
117.0
249.0
5.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0254956 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
None
1-29; 3-18; 8-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0264203 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Salmonella serotype krefeld
PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0271464 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0273645 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
None
1-29; 3-18; 8-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0274736 VERIFIED: YES
Provenance & Taxonomy
Golden hamster or [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It contains three disulfide bonds: 1,29; 3,18; 8,28
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa
25.8 μg/mL
IC50
PaperIsolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.
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