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MYP_080248
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Basic Information
Aesculus hippocastanum antimicrobial protein 1 (Ah-AMP1; Cys-rich; Plant defensin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Plant bioactivity ▸ Plant defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
50 amino acids
C245H355N79O75S8
Standard
Sequence
LCNERPSQTWSGNCGNTAHCDKQCQDWEKASHGACHKRENHWKCFCYFNC
Physicochemical Analysis
5863.44 Da
7.73
1.04
0.50
0.0207
-1.17
0.46
-0.24
40.34
13.80
0.1200
17990.00
18490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2523.00
-31.93
94.0
88.0
189.0
407.0
14.0
57.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0137269 VERIFIED: YES
Provenance & Taxonomy
Aesculus hippocastanum [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Verticilium albo-atrum
6 μg/mL
IC50
PMID7628617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0140834 VERIFIED: YES
Provenance & Taxonomy
Aesculus hippocastanum [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Penicillium digitatum
25 μg/mL
IC50
PaperPubMed PMID 10591099 | PubMed PMID 7628617 PMID10591099;7628617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10591099/
RECORD: Rec_0155317 VERIFIED: YES
Provenance & Taxonomy
Aesculus hippocastanum [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Neurospora crassa
0.8 μg/mL
IC50
PaperPubMed PMID 10591099 | PubMed PMID 7628617 PMID10591099;7628617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10591099/
RECORD: Rec_0155868 VERIFIED: YES
Provenance & Taxonomy
Aesculus hippocastanum [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
[MA: Botrytis cinerea
25 μg/mL
IC50
PaperIsolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. FEBS Lett. 1995 Jul 17;368(2):257-262. doi: 10.1016/0014-5793(95)00666-W. PMID: 7628617. | PubMed PMID: 10591099 | PubMed PMID: 10656585 PMID7628617;10591099;10656585 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0156341 VERIFIED: YES
Provenance & Taxonomy
Aesculus hippocastanum [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Trichoderma viride
100 μg/mL
IC50
PaperPubMed PMID 10591099 | PubMed PMID 7628617 PMID10591099;7628617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10591099/
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