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MYP_080248
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Basic Information
Aesculus hippocastanum antimicrobial protein 1 (Ah-AMP1; Cys-rich; Plant defensin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Plant bioactivity ▸ Plant defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
50 amino acids
C245H355N79O75S8
Standard
Sequence
LCNERPSQTWSGNCGNTAHCDKQCQDWEKASHGACHKRENHWKCFCYFNC
Physicochemical Analysis
5863.44 Da
7.73
1.04
0.50
0.0207
-1.17
0.46
-0.24
40.34
13.80
0.1200
17990.00
18490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2523.00
-31.93
94.0
88.0
189.0
407.0
14.0
57.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0333092 VERIFIED: YES
Provenance & Taxonomy
Aesculus hippocastanum [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Cladosporium sphaerospermum
0.5 μg/mL
IC50
PaperPubMed PMID 10591099 | PubMed PMID 7628617 PMID10591099;7628617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10591099/
RECORD: Rec_0333125 VERIFIED: NO
Provenance & Taxonomy
Aesculus hippocastanum [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Fungicide Plant Defense Non-hemolytic Non-ribosomal
Qualitative functional evidence
PMID10656585 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10656585/; https://www.uniprot.org/uniprotkb/Q7M1F3/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0335683 VERIFIED: YES
Provenance & Taxonomy
Aesculus hippocastanum [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Fusarium culmorum
0.7 μg/mL
IC50
PaperPubMed PMID 10591099 | PubMed PMID 7628617 PMID10591099;7628617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10591099/
RECORD: Rec_0338680 VERIFIED: YES
Provenance & Taxonomy
Aesculus hippocastanum [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Trichoderma viride
100 μg/mL
IC50
PMID7628617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0338898 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
PaperPatent US 6605698 B1 Evidence URLhttps://patents.google.com/patent/US6605698B1/en PatentUS 6605698 B1
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