Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length141 amino acids

Chemical FormulaC685H1089N195O191S5

DescriptionStandard

        PTALPAAHEPMLLLAITEFVANSAAFAYFTAGALHRNISSNMLPRRFPLQLRTKSMGVFSPQLQERYPDQPMELHLSARRQPLLSCHPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITGNRLGGTVSLRG
    

Molecular Weight15272.49 Da

Isoelectric Point (pI)10.01

Net Charge (pH 7.0)4.40

Net Charge (pH 7.4) 4.06

Charge Density (pH 7.0) 0.0312

GRAVY Index0.06

Hydrophobic Moment 0.57

Boman Index0.11

Instability Index53.16

Aliphatic Index 93.55

Aromaticity 0.0709

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6072.60

LogP -61.07

H-bond Donors 209.0

H-bond Acceptors 205.0

Rotatable Bonds 484.0

Heavy Atoms 1076.0

Ring Count 28.0

Amide Bonds 152.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0119149 VERIFIED: NO

Provenance & Taxonomy

OrganismAptenodytes forsteri [Animal]

FamilyBPI/LBP

Tax ID9233

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria