Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length437 amino acids

Chemical FormulaC2193H3460N572O609S16

DescriptionStandard

        MARGADNTLSDSTLVALAGPGTAVTAGVFFARITQKGLDYACQQGVATLRKELEKITIPTFSGSFKIKYFGKGRYNFYSKASGNFDLSVEGISVLASLRLGYDPTSGHSTVSCSSCRSHINRVHVRTSGSSLKWLIQLFHRNIESALRKAMESKICKMLTNTVSSKLQPYFQTLPVTAKVDRMVGINYSLVAPPKATAENLDGLLKGEFFSLDHPSPPPFAPPALALPADHDRMVYLCISEYFFNTAGLVYQKAGVLNLTINNSMIPKKSLFSLTTNFFGTLIPKVSTMFPNMEMQFLIWASFPPHLAVHPSGLDLTFVLETQAFAVLPNASLAPLFRIEMNSSISVDIGVRSKRLIGELRLNKLLLELKHSNIGPFSVELLQAVMNFAVPTLVLPKINEKLQRGFPLPLPAYIQLSNLVLQPHQDFLLFGADVRYS
    

Molecular Weight48095.44 Da

Isoelectric Point (pI)9.47

Net Charge (pH 7.0)13.34

Net Charge (pH 7.4) 12.46

Charge Density (pH 7.0) 0.0305

GRAVY Index0.13

Hydrophobic Moment 0.81

Boman Index0.14

Instability Index34.39

Aliphatic Index 98.19

Aromaticity 0.0961

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0183311 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBPI/LBP

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence