Peptide Database

Peptide NameK5-66

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC161H244N38O48S

DescriptionStandard

        GELGRLVYLLDGPGYDPIHCSLAYGDASTLVVF
    

Molecular Weight3511.95 Da

Isoelectric Point (pI)4.22

Net Charge (pH 7.0)-3.16

Net Charge (pH 7.4) -3.44

Charge Density (pH 7.0) -0.0957

GRAVY Index0.48

Hydrophobic Moment 0.41

Boman Index0.31

Instability Index10.90

Aliphatic Index 115.15

Aromaticity 0.1212

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1338.10

LogP -9.69

H-bond Donors 47.0

H-bond Acceptors 47.0

Rotatable Bonds 107.0

Heavy Atoms 248.0

Ring Count 7.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0346976 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Protease inhibitor Replication inhibitor

TargetHepatitis C virus (Replication); Escherichia coli

Activity0.0207 μM

MethodFRET assay

PaperHigh affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants. | Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J. | J Biol Chem. 2012 | PMID:22965230 PMID22965230 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22965230/

RECORD: Rec_0384843 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 0.0%, T 33.3%, C 66.7% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial