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MYP_080068
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Basic Information
Brevinin-1HSa
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C121H204N30O27S2
Standard
Sequence
FLPAVLRVAAKIVPTVFCAISKKC
Physicochemical Analysis
2575.23 Da
9.85
3.74
3.50
0.1557
1.26
0.65
0.32
34.61
130.00
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
895.46
-4.18
33.0
33.0
81.0
180.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0241786 VERIFIED: YES
Provenance & Taxonomy
Odorrana hosii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
24.0 μM
MIC
PaperJ.M. Conlon et al. / Toxicon 52 (2008) 465-473. Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae) PMID18621071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18621071/
RECORD: Rec_0282646 VERIFIED: YES
Provenance & Taxonomy
Rana hosii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25726
24 μM
MIC
PMID18621071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18621071/
RECORD: Rec_0288783 VERIFIED: YES
Provenance & Taxonomy
Odorrana hosii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli
PaperCharacterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae) PMID18621071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18621071/
RECORD: Rec_0347291 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
Brevinin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID18621071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18621071/
RECORD: Rec_0359956 VERIFIED: YES
Provenance & Taxonomy
Odorrana hosii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PaperCharacterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae) PMID18621071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18621071/
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