Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length426 amino acids

Chemical FormulaC2192H3399N551O617S28

DescriptionStandard

        MVGFCFNCLCEVIPDFDSQEGHQEELTVDKMMIKVFCLVLLFSLNCSLDFNHGITMRVNQKCIDYVKNFGMEFLKKKLMNQMLPDMTGSTTKFGKGEFLLSGIKVEELQLPKSAALPKAPANIVVSIEDASVNASGNWKMHHWLVNNSGKFVLNLSNVAIKARLSTFWNDFRRPSVLLDDCQSSVGKAKVHFSGKRKWLYNLFSGFLDKPIRTNLNAKLCPKVKDIINSLNRKLDTFLVVTKPDAYIDIHYSLLEKPKTTDRYIDLYLMGKARPAGNPVEYALSPKPIPLPDDNNYMLYVGFPTDFFHTLAASYFMANALERTITPKDFPEAFWLSTDGYNHTFSEITLHYPEACPMEMIVMATQAPAVSLTPNSLTLTMFGFLKAYALLPDSLEPLFSMYLEADLCTHDLQMSQLNLTSNFILTR
    

Molecular Weight48240.58 Da

Isoelectric Point (pI)6.79

Net Charge (pH 7.0)-0.69

Net Charge (pH 7.4) -1.68

Charge Density (pH 7.0) -0.0016

GRAVY Index-0.03

Hydrophobic Moment 0.76

Boman Index0.10

Instability Index34.33

Aliphatic Index 89.27

Aromaticity 0.1103

Extinction Coeff. Reduced 48360.00

Extinction Coeff. Oxidized 48985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425825 VERIFIED: NO

Provenance & Taxonomy

OrganismGeotrypetes seraphini (Gaboon caecilian) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria