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MYP_079815
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Basic Information
Alyteserin-1b
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
23 amino acids
C105H177N29O28
Standard
Sequence
GLKEIFKAGLGSLVKGIAAHVAN
Physicochemical Analysis
2293.71 Da
9.70
1.85
1.59
0.0803
0.63
0.48
0.31
-4.61
127.39
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
910.88
-7.46
31.0
31.0
79.0
162.0
2.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0340240 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0345983 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Alyteserin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
25.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 30 (2009) 1069-1073. The alyteserins: Two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae)
RECORD: Rec_0356157 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Plant]
Alyteserin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Hemolytic
human erthrocytes
210 μM
LC50
PMID19463738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19463738/
RECORD: Rec_0395568 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
25 μM
MIC
PMID19463738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19463738/
RECORD: Rec_0426780 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Frog skin active peptide (FSAP); Alyteserin-1 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Hemolytic
PMID19463738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19463738/
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