Peptide Database

Peptide NameVEGFA

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length206 amino acids

Chemical FormulaC1018H1633N319O297S25

DescriptionStandard

        APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
    

Molecular Weight23894.44 Da

Isoelectric Point (pI)9.16

Net Charge (pH 7.0)15.34

Net Charge (pH 7.4) 14.42

Charge Density (pH 7.0) 0.0745

GRAVY Index-0.95

Hydrophobic Moment 0.58

Boman Index-0.27

Instability Index57.99

Aliphatic Index 48.69

Aromaticity 0.0631

Extinction Coeff. Reduced 19940.00

Extinction Coeff. Oxidized 21065.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0245565 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsHomodimer formed by interchain disulphide bonds between cysteine residues at positions 51 and 60; further disulphide bonds formed between cysteine residues at positions 26 and 68, 57 and 102, and 61 and 104. Lysine residues at positions 121, 123 and 126 are N6-acetyllysine. N-linked glycosylation of asparagine residue at position 75

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

Targetfms related receptor tyrosine kinase 1 (Human); kinase insert domain receptor (Human)

Activity10 nM

MethodKd