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MYP_079802
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Basic Information
Leucrocin I
Anticancer
Anticancer ▸ Antitumor
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
7 amino acids
C36H56N10O11
Standard
Sequence
NGVQPKY
Physicochemical Analysis
804.89 Da
8.59
0.76
0.55
0.1083
-1.43
0.17
-0.17
14.61
41.43
0.1429
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
361.56
-3.68
11.0
12.0
24.0
57.0
2.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012020 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0065358 VERIFIED: YES
Provenance & Taxonomy
Crocodylus siamensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes (13% Hemolysis at 12 microg/ml, Human erythrocytes (11% Hemolysis at 24 microg/ml, Human erythrocytes (16% Hemolysis at 48 microg/ml
12 μg/mL
Hemolysis
PMID21184776;23831136;27129462;24192554 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21184776/
RECORD: Rec_0072535 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. typhi DMST 22842
200
MIC
PMID23831136 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23831136/
RECORD: Rec_0079800 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
V. cholerae non O1, non-O139
200
MIC
PMID23831136 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23831136/
RECORD: Rec_0128694 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis ATCC 12228
200
MIC
PMID23831136 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23831136/
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