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MYP_079710
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Basic Information
Grammistin Pp4a
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Ichthyotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
24 amino acids
C127H206N30O26
Standard
Sequence
LFGFLIPLLPHIIGAIPQVIGAIR
Physicochemical Analysis
2569.18 Da
9.76
0.85
0.59
0.0353
1.60
0.47
0.64
31.32
182.92
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.92
0.10
27.0
28.0
78.0
183.0
6.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0150900 VERIFIED: YES
Provenance & Taxonomy
Grammistes sexlineatus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Aeromonas salmonicida NCIBM 1102
50 μg/mL
MIC
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP02377
RECORD: Rec_0201253 VERIFIED: YES
Provenance & Taxonomy
Grammistes sexlineatus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Vibrio parahaemolyticus
25 μg/mL
MIC
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP02377
RECORD: Rec_0245167 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hemolytic Ichthyotoxic
Horse erythrocytes
0.19 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/10669014/ PMID10669014 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10669014/
RECORD: Rec_0265161 VERIFIED: NO
Provenance & Taxonomy
Pogonoperca punctata [Animal]
Grammistin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Cytolytic Toxin Hemolytic Ichthyotoxic Non-ribosomal
Qualitative functional evidence
Evidence URLhttps://www.uniprot.org/uniprotkb/P69837/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0284567 VERIFIED: YES
Provenance & Taxonomy
Grammistes sexlineatus [Animal]
Grammistin; Group 1 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Cytolytic Toxin Hemolytic Ichthyotoxic
PMID10669014;15777955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10669014/
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