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MYP_079658
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Basic Information
YIK-C16(625-656)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
36 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
EMTWEEWEKKIEEYIKKIEEILKKSQNQQIDLGSGX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0148622 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 36
Bio-Activity Profile
Antiviral
HIV-1 BaL
PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0160751 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 36 indicates PEG4-Lys-C16(Palmitic Acid)
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of cell-cell fusion between H9/IIIB cells and MT-2 cells
0.00055 μM
IC50
PaperPubMed PMID: 30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0171964 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 36 indicates PEG4-Lys-C16(Palmitic Acid)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 NL4-3 D36G(6 T-20 resistant strains, WT,V38A,V38A/N42D,V38E/N42S,V38A/N42T,N42T/N43K):inhibition of virus infection in MT-2 cells
0.00004-0.000179 μM
IC50
PaperPubMed PMID: 30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0199506 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 36 indicates PEG4-Lys-C16(Palmitic Acid).
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 LAI (7 T2635-Resistant Strains,WT,A6V,Q66R,K90E,K154Q,Q79E/N126K,K90E/N126K) | MT-2 cells
0.000065-0.000106 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperA Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life. | Su S, Rasquinha G, Du L, Wang Q, Xu W, Li W, Lu L, Jiang S. | Molecules. 2019 Mar 21;24(6):1134. | DOI:10.3390/molecules24061134 | PMID:30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0208002 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 36 indicates PEG4-Lys-C16(Palmitic Acid).
Bio-Activity Profile
Antiviral Fusion inhibition
inhibition of cell-cell fusion between H9/IIIB cells and MT-2 cells
0.00055 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperA Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life. | Su S, Rasquinha G, Du L, Wang Q, Xu W, Li W, Lu L, Jiang S. | Molecules. 2019 Mar 21;24(6):1134. | DOI:10.3390/molecules24061134 | PMID:30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
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