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MYP_079635
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Basic Information
Phylloseptin-S2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
19 amino acids
C98H154N24O23
Standard
Sequence
FLSLIPHIVSGVASLAKHF
Physicochemical Analysis
2036.42 Da
8.76
0.93
0.63
0.0491
1.23
0.49
0.50
21.16
143.68
0.1053
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
722.40
-3.63
25.0
26.0
63.0
145.0
5.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0301403 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
S. cerevisiae
6.25 μM
MIC
PaperStructure, antimicrobial activities and mode of interaction with membranes of novel [corrected] phylloseptins from the painted-belly leaf frog, Phyllomedusa sauvagii
RECORD: Rec_0327397 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0353124 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: THP-1
22.5 μM
IC50
PMID23967105 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23967105/
RECORD: Rec_0358844 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Human acute monocytic leukemia THP-1
22.5 μM
IC50
PMID23967105 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23967105/
RECORD: Rec_0370789 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Leishmania infantum MHOM/MA/67/ITMAP-263
18.5 μM
IC50
PMID23967105 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23967105/
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