Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length486 amino acids

Chemical FormulaC2387H3754N604O719S15

DescriptionStandard

        MSLPQETLVSHNMRLFLAVIVLITPTSGETPAVHVSLTDKALHYGAYVGAQWMTDKLKDVSIPDISGEIYILFDNLHYTLMGITIENVEFPEPSVEFYPGRGLDTSVSDVSVTLTGGWITRFGLIQDGGTFQMIVFDTDVTFAVQLGRGVGGHPFVTSVNCEAHVGGVDMQFRGGASWIFQPFVSKYRDRVRGEIEDKICPQLKESIIMLDYRLQVFGVSIDVNKDLTLDLGLTDDPVIDVSSLNVGLKGVIYSIKTHAEPPSEPQPFSLAEQPDSMLTLGVSEFTLNSASYAYYSAGLLQILLNDSMIPSYSPVHLNTSSFGAFIPQLPKMYPGLLMNLQLYAREVPVVSFQPGLVTLDLQGAVKAYAIQPTGAQIPLFTLNTDSKFSGKVWTAGGRLKGSAEMKNLTVTLEATEIGGFETAALENLARVGAKLAITKLNQRLGKGVELPRLKHAELTNTTLEVEMGFITISTDAQISLTEDSTD
    

Molecular Weight52897.93 Da

Isoelectric Point (pI)4.84

Net Charge (pH 7.0)-19.66

Net Charge (pH 7.4) -20.48

Charge Density (pH 7.0) -0.0405

GRAVY Index0.11

Hydrophobic Moment 0.71

Boman Index0.16

Instability Index33.16

Aliphatic Index 99.44

Aromaticity 0.0844

Extinction Coeff. Reduced 44350.00

Extinction Coeff. Oxidized 44475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0161575 VERIFIED: NO

Provenance & Taxonomy

OrganismTakifugu rubripes [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence