‹ ›
MYP_079484
← PREVIOUS NEXT → BACK
Basic Information
E2EM15W-S3
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
15 amino acids
C77H131N21O20
Standard
Sequence
TLKQWAKGVGKDLVK
Physicochemical Analysis
1670.99 Da
10.00
2.40
2.20
0.1597
-0.48
0.64
-0.08
-9.49
97.33
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
691.21
-4.77
24.0
23.0
59.0
118.0
2.0
15.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0117657 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Shigella dysenteriae
50 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0129950 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumonia
50 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0182960 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Salmonella typhimurium
>200 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0345251 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
100 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
FIRST PREV 1 2
Showing 4 records on this page · Page 2 of 2