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MYP_079477
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Basic Information
Interferon Alfa-2a, Recombinant
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Immunology ▸ Immune modulation ▸ Cytokine modulation
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Immunomodulation ▸ Immunosuppressive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
165 amino acids
C860H1353N227O255S9
Standard
Sequence
CDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE
Physicochemical Analysis
19240.90 Da
5.99
-1.98
-2.45
-0.0120
-0.34
0.62
-0.04
49.96
85.70
0.1030
18450.00
18700.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
7849.42
-75.28
275.0
265.0
654.0
1351.0
27.0
180.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0293495 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
alpha/beta interferon family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
1-98; 29-138
Bio-Activity Profile
Cytokine Growth factor alpha beta interferon family Antiviral Host defense
PaperPDB 2HYM structural record; NMR; chain B; residues 1-165
RECORD: Rec_0322619 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Interferon
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Antiviral Anticancer Immunomodulatory Enzyme replacement
The IM half-life of interferon alfa-2a is 6 hours to 8 hours; the half-life for IV infusion is 3.7 hours to 8.5 hours (mean 5.1 hours).
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1245
RECORD: Rec_0333586 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Interferon
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Antiviral Anticancer Immunomodulatory
The IM half-life of interferon alfa-2a is 6 hours to 8 hours; the half-life for IV infusion is 3.7 hours to 8.5 hours (mean 5.1 hours).
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1245
RECORD: Rec_0422956 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Interferon
9606
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
Glycosylation, Phosphorylation
Bio-Activity Profile
Antiviral Anticancer Immunomodulatory Enzyme replacement
10 hours (Escherichia coli, in vivo)
RECORD: Rec_0426197 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Interferon
9606
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
Glycosylation, Phosphorylation
Bio-Activity Profile
Antiviral Immunomodulatory Enzyme replacement
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