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MYP_079477
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Basic Information
Interferon Alfa-2a, Recombinant
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Immunology ▸ Immune modulation ▸ Cytokine modulation
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Immunomodulation ▸ Immunosuppressive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
165 amino acids
C860H1353N227O255S9
Standard
Sequence
CDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE
Physicochemical Analysis
19240.90 Da
5.99
-1.98
-2.45
-0.0120
-0.34
0.62
-0.04
49.96
85.70
0.1030
18450.00
18700.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
7849.42
-75.28
275.0
265.0
654.0
1351.0
27.0
180.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0128783 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Interferon
32630
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Immunomodulatory Enzyme replacement
IM half-life of interferon alfa-2a is 6 hours to 8 hours
Evidence URLhttps://patents.google.com/patent/CA2172664/en PatentCA2172664
RECORD: Rec_0153372 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Interferon
9606
Structure & Mods
linear multidomain protein biologic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory Immunosuppressive Antiviral
10 h (Escherichia coli, in vivo)
PaperPubMed-linked source references: PMID:9537453; PMID:9305672; PMID:1861694; PMID:2016626; PMID:3046638; PMID:3170795; PMID:3278186; PMID:3488481; PMID:3016426 PMID9537453;9305672;1861694;2016626;3046638;3170795;3278186;3488481;3016426 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9537453/
RECORD: Rec_0192932 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Interferon
9606
Structure & Mods
linear multidomain protein biologic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Antiviral Immunomodulatory
IM half-life of interferon alfa-2a is 6 h to 8 h
PaperPubMed-linked source references: PMID:3598612 PMID3598612 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3598612/ PatentCA2172664
RECORD: Rec_0210713 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Interferon
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-HIV Immunomodulatory
Human immunodeficiency virus 1
PMID3016426 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3016426/
RECORD: Rec_0219825 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Interferon
9606
Structure & Mods
linear multidomain protein biologic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Immunomodulatory
20 h (yeast, in vivo)
PaperPubMed-linked source references: PMID:9537453; PMID:9305672; PMID:1861694; PMID:2016626; PMID:3046638; PMID:3170795; PMID:3278186; PMID:3488481; PMID:3016426 PMID9537453;9305672;1861694;2016626;3046638;3170795;3278186;3488481;3016426 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9537453/
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