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MYP_079395
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Basic Information
Shiva-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
38 amino acids
C189H322N64O45S
Standard
Sequence
MPRWRLFRRIDRVGKQIKQGILRAGPAIALVGDARAVG
Physicochemical Analysis
4243.05 Da
12.00
6.50
6.28
0.1711
-0.10
1.12
-0.10
61.72
107.89
0.0526
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1784.35
-14.80
65.0
53.0
143.0
299.0
5.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0221429 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 6872705 B2 Evidence URLhttps://patents.google.com/patent/US6872705B2/en PatentUS 6872705 B2
RECORD: Rec_0236093 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
DLD-1
100.0 μM
IC50
PaperCancerPPD2 curated year-page record; primary PMID 7849420 (1995), additional curated PMID 21403917. PMID7849420;21403917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7849420/
RECORD: Rec_0261135 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cecropin/Melittin hybrid
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium berghei
10 μM
Percent inhibition; Microscopy (Giemsa staining)
PaperAntimicrobial peptide action on parasites PMID22664071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22664071/
RECORD: Rec_0339149 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Antiparasitic Antiplasmodial Antitrypanosomal Lytic Peptide
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0346479 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID7849420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7849420/
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