Peptide Database

Peptide NameSiltuximab

Function Ontology

Anticancer

Antiviral

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length449 amino acids

Chemical FormulaC2204H3402N576O676S16

DescriptionStandard

        EVQLVESGGKLLKPGGSLKLSCAASGFTFSSFAMSWFRQSPEKRLEWVAEISSGGSYTYYPDTVTGRFTISRDNAKNTLYLEMSSLRSEDTAMYYCARGLWGYYALDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
    

Molecular Weight49297.08 Da

Isoelectric Point (pI)8.35

Net Charge (pH 7.0)4.54

Net Charge (pH 7.4) 3.63

Charge Density (pH 7.0) 0.0101

GRAVY Index-0.39

Hydrophobic Moment 0.64

Boman Index0.02

Instability Index47.87

Aliphatic Index 69.38

Aromaticity 0.1002

Extinction Coeff. Reduced 80790.00

Extinction Coeff. Oxidized 81415.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006121 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Mus musculus [Animal]; Cricetulus griseus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10090;10029

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Anticancer Immunomodulatory Enzyme replacement

TargetCHO

Half-LifeThe mean terminal half life after the first intravenous infusion of 11 mg/kg is 20.6 days.