Peptide Database

Peptide NameLR(3) insulin-like growth factor-I (IGF-I)

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Tissue repair / Regeneration ▸ Bone regeneration

Standard StatusStandard

Sequence Length83 amino acids

Chemical FormulaC400H625N111O115S9

DescriptionStandard

        MFPAMPLSSLFVNGPRTLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
    

Molecular Weight9117.50 Da

Isoelectric Point (pI)8.62

Net Charge (pH 7.0)2.45

Net Charge (pH 7.4) 2.13

Charge Density (pH 7.0) 0.0295

GRAVY Index-0.07

Hydrophobic Moment 0.49

Boman Index0.02

Instability Index65.72

Aliphatic Index 64.70

Aromaticity 0.1084

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3595.80

LogP -37.47

H-bond Donors 131.0

H-bond Acceptors 127.0

Rotatable Bonds 290.0

Heavy Atoms 635.0

Ring Count 16.0

Amide Bonds 86.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0012815 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyIGF

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsI125 labeling

Bio-Activity Profile

Function

Osteogenic stimulates body protein and glucose metabolism and increases glomerular filtration rate and renal plasma flow

MethodRadioimmunoassay and bi-exponential equation that describes a two-compartment model

Half-LifeIntravenous bolus administration in Rat, in vivo; 276 s

RECORD: Rec_0425819 VERIFIED: YES