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MYP_079257
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Basic Information
peptide 29
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
20 amino acids
C121H211N51O23
Standard
Sequence
LQQLLFIHFRIARRRRRRRR
Physicochemical Analysis
2748.30 Da
12.00
8.85
8.59
0.4424
-1.15
0.57
-0.80
236.90
102.50
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1288.18
-10.79
51.0
33.0
97.0
195.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0094686 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Integrase inhibition
inhibition of strand transfer catalyzed by integrase
0.09±0.01 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0277243 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
0.09±0.01 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0306008 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
0.09±0.01 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0377936 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
0.09±0.01 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0390474 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/