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MYP_079130
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Basic Information
Ranacyclin-B-RN2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
19 amino acids
C87H138N24O24S2
Standard
Sequence
SALVGCGTKSYPPKPCFGR
Physicochemical Analysis
1968.30 Da
9.38
2.44
2.20
0.1283
-0.23
0.26
0.03
9.23
41.05
0.1053
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
755.61
-8.80
28.0
29.0
58.0
137.0
5.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0056079 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
127021
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
6-16
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
12.7 μM
MIC
PaperBi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins
RECORD: Rec_0252495 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Ranacyclin
127021
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus ATCC 25923
12.7 μM
MIC
PMID21927839 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21927839/
RECORD: Rec_0329069 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0338170 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 42.1%, C 57.9% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0354587 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
12.7 μM
MIC
PMID21927839 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21927839/
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