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MYP_079094
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Basic Information
Defensin-derived D-Peptide A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
9 amino acids
C53H95N21O11
Standard
Sequence
RLYLRIGRR
Physicochemical Analysis
1202.46 Da
12.00
3.76
3.55
0.4177
-0.84
0.99
-0.65
93.93
130.00
0.1111
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
563.95
-3.95
23.0
15.0
41.0
85.0
1.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0110174 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Pseudomonas aeruginosa
30 μg/mL
MIC
PMID19584534;15003352;19154767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19584534/
RECORD: Rec_0131997 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
L-type peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antitrypanosomal Antiparasitic
Trypanosoma brucei brucei ILTat 1.1 (blood stage form)
20 μM
Microscopy (Neubauer hemocytometer)
PaperAntiparasitic peptides PMID23615879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23615879/
RECORD: Rec_0149531 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Staphylococcus aureus ATCC 6538P
2 μg/mL
MIC
PMID19584534;15003352;19154767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19584534/
RECORD: Rec_0162056 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Human glioblastoma U251-MG
589
IC50
PMID19584534;15003352;19154767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19584534/
RECORD: Rec_0195028 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID19154767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19154767/
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