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MYP_079031
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Basic Information
Rugosin-RN
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C153H276N42O46S2
Standard
Sequence
SIRDKIKTIAIDLAKSAGTGVLKTLICKLDKSC
Physicochemical Analysis
3504.21 Da
9.51
3.44
3.19
0.1042
0.26
0.55
0.02
-1.01
124.24
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1445.82
-14.25
54.0
52.0
126.0
243.0
0.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0242287 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperPeptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata. Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. PMID: 19778602. PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0244076 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0253140 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
127021
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Bacillus subtilis
9.38 μg/mL
MIC
PaperPeptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovitt
RECORD: Rec_0256938 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 63.6%, E 0.0%, T 18.2%, C 18.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Antifungal Hemolytic
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0267733 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Rugosin
127021
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC2002
5.63 μg/mL
MIC
PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
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