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MYP_079031
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Basic Information
Rugosin-RN
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C153H276N42O46S2
Standard
Sequence
SIRDKIKTIAIDLAKSAGTGVLKTLICKLDKSC
Physicochemical Analysis
3504.21 Da
9.51
3.44
3.19
0.1042
0.26
0.55
0.02
-1.01
124.24
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1445.82
-14.25
54.0
52.0
126.0
243.0
0.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0102989 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli ML-35P
25 μg/mL
MIC
PaperPeptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata. Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. PMID: 19778602. PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0109766 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans ATCC2002
5.63 μg/mL
MIC
PaperPeptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata. Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. PMID: 19778602. PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0135131 VERIFIED: NO
Provenance & Taxonomy
Rana nigrovittata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
RECORD: Rec_0138981 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Rugosin
127021
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ML-35P
25 μg/mL
MIC
PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0141164 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Rugosin
127021
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal Mast cell degranulation
PaperY. Ma et al. / Genomics 95 (2010) 66-71. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
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