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MYP_079026
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Basic Information
Geobacillin II
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
27 amino acids
C139H225N39O34S5
Standard
Sequence
STIVCVSLRICNWSLRFCPSFKVRCPM
Physicochemical Analysis
3146.84 Da
9.37
3.42
3.15
0.1266
0.66
0.60
0.10
24.01
90.00
0.1111
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.09
-10.01
47.0
43.0
98.0
217.0
6.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026618 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans NG80-2 [other]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus cereus Z4222
PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0097046 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0126381 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 40.7%, E 0.0%, T 33.3%, C 25.9% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0260345 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Cyclization
Four lanthionines (S3-C7,S23-C27,S26-C30,S29-C33) and three β-methyllanthionines (T8-C11; T13-C18; T20-C24),S5 is dehydroalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus cereus Z4222
PaperPubMed PMID: 22431611 PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0289988 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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