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MYP_078954
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Basic Information
Nigrocin-HLM
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
15 amino acids
C70H121N17O17
Standard
Sequence
GLLSGILGAGKKIVF
Physicochemical Analysis
1472.81 Da
10.00
1.76
1.55
0.1172
1.27
0.48
0.50
-6.13
156.00
0.0667
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
542.99
-2.89
19.0
19.0
51.0
104.0
1.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0261865 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Nigrocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Clinical MRSA strains
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
11.77
MIC
PMID30555431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30555431/
RECORD: Rec_0287873 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylarana latouchii [Synthetic]
Nigrocin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus NCTC10788
2.9 μM
MIC
PaperModification Targeting the "Rana Box" Motif of a Novel Nigrocin Peptide From Hylarana latouchii Enhances and Broadens Its Potency Against Multiple Bacteria
RECORD: Rec_0292010 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Nigrocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Clinical MRSA strains
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
DTMR37
1.47
MIC
PMID30555431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30555431/
RECORD: Rec_0347296 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylarana latouchii [Synthetic]
Nigrocin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
resistant pathogens such as MRSA
1-4 μM
MIC
PaperModification Targeting the "Rana Box" Motif of a Novel Nigrocin Peptide From Hylarana latouchii Enhances and Broadens Its Potency Against Multiple Bacteria
RECORD: Rec_0405664 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Nigrocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Clinical MRSA strains
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
47.08
MIC
PMID30555431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30555431/
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