Peptide Database

Peptide NameSLAY-screened peptide P5327

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC105H163N31O31S

DescriptionStandard

        PTSAYLPHEGRWSLRSSCLIN
    

Molecular Weight2387.67 Da

Isoelectric Point (pI)8.64

Net Charge (pH 7.0)1.04

Net Charge (pH 7.4) 0.91

Charge Density (pH 7.0) 0.0494

GRAVY Index-0.41

Hydrophobic Moment 0.50

Boman Index-0.02

Instability Index109.93

Aliphatic Index 79.05

Aromaticity 0.0952

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 992.58

LogP -10.95

H-bond Donors 38.0

H-bond Acceptors 34.0

Rotatable Bonds 73.0

Heavy Atoms 168.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0230252 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/