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MYP_078914
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Basic Information
Ostricacin-4 (Beta-defensin 8; Birds, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
42 amino acids
C205H323N65O54S6
Standard
Sequence
LPVNEAQCRQVGGYCGLRICNFPSRFLGLCTRNHPCCSRVWV
Physicochemical Analysis
4754.55 Da
8.98
3.79
3.45
0.0902
0.03
0.66
-0.01
44.37
76.43
0.0952
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1917.69
-20.40
73.0
65.0
148.0
330.0
9.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198308 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-36, 15-30, 20-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli O157:H7
12.03 μg/mL
MIC
PMID16459058 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16459058/
RECORD: Rec_0213652 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli O157:H7
12.03 μg/mL
MIC
PMID16459058 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16459058/
RECORD: Rec_0256968 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus 1056 MRSA
11.48 μg/mL
MIC
PaperIdentification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins.
RECORD: Rec_0264785 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 1056 MRSA
11.48 μg/mL
MIC
PMID16459058 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16459058/
RECORD: Rec_0293985 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Beta-defensin; Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Anti-MRSA Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli
PMID16459058 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16459058/
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