Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length508 amino acids

Chemical FormulaC2551H3961N633O746S23

DescriptionStandard

        MKPSLSCMYKLYSLVEATTRLLLSSKSVTKAKMWLVTAFLLMAITQTHADYASLQAVLSQNGLQKVSHWMTDWLQKELSTITLPEVSGSVDIFLGSVYYVLHDMTINRCDLPEPSVAYSEGTGVSLQVNGLSLVISGHWNTKFGLIHDSGWFDLAIFGTNLETLLGFQKTEDYLSISTLTCFANVGGVEIHFHGGGSFIFQPFVDEFSGEITDMIRERICPAFQQAIENVDRVLAASETIKLDPFVYLNVSLTDSPVVFQNGFELNVKGEFYSARCPSEPPFSPNHFDLQWQADYMMSVGISEFCVNSAAFAYFKSGVMNITITDGMIPKGSPIHLNTSQFGSLIPQLPKKYPDMEMEIVLYASDNPKISFNHTVISLDVSAAAKFYAIDTHTGLIPLFRLDMQYSFTAQVQIDKQLLTGFLKMKNMTIALGSSEIGSFSTEAIERIGRLALSTIVLPKLNAQLKDGLPLPSVKGFSLTNSVMTVKNGFLILATDINRPADFLQSDKL
    

Molecular Weight56171.03 Da

Isoelectric Point (pI)5.32

Net Charge (pH 7.0)-12.55

Net Charge (pH 7.4) -13.52

Charge Density (pH 7.0) -0.0247

GRAVY Index0.15

Hydrophobic Moment 0.79

Boman Index0.18

Instability Index37.29

Aliphatic Index 96.14

Aromaticity 0.1043

Extinction Coeff. Reduced 55350.00

Extinction Coeff. Oxidized 55725.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0373512 VERIFIED: YES

Provenance & Taxonomy

OrganismSilurus meridionalis [Animal]

FamilyBPI LBP Plunc super, BPI LBP

Tax ID175797

Structure & Mods

Configgene-encoded linear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria