MYP_078816
Cacaoidin
Antimicrobial
Standard
23 amino acids
C94H146N24O34S2
Standard
SSAPCTIYASVSASISATASWGC
2220.44 Da
5.24
-0.56
-0.80
-0.0244
0.70
0.21
0.34
43.00
68.26
0.0870
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
912.82
-14.71
36.0
36.0
64.0
154.0
4.0
22.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0148296
VERIFIED: YES
Provenance & Taxonomy
Streptomyces cacaoi [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Thioether bonds between S1 and C5, and T18 and C23. In addition, C23 is dehydrated to form a double bond between Calpha and carbonyl carbons. There are likely multiple D-amiino acids. N-terminally motified, S2, T6 dehydrated, Y8 is O-glycosylated, S10, S12, S14, and S16 became D-alanines
Bio-Activity Profile
Antimicrobial
Bacillus subtilis 168
3.4 μM
MIC
RECORD: Rec_0173960
VERIFIED: YES
Provenance & Taxonomy
Streptomyces cacaoi [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Thioether bonds between S1 and C5, and T18 and C23. In addition, C23 is dehydrated to form a double bond between Calpha and carbonyl carbons. There are likely multiple D-amiino acids. N-terminally motified, S2, T6 dehydrated, Y8 is O-glycosylated, S10, S12, S14, and S16 became D-alanines
Bio-Activity Profile
Antimicrobial
clinical isolates C. difficile RyC 11872343 toxigenic
3.4 μM
MIC
RECORD: Rec_0223827
VERIFIED: YES
Provenance & Taxonomy
Streptomyces cacaoi [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Thioether bonds between S1 and C5, and T18 and C23. In addition, C23 is dehydrated to form a double bond between Calpha and carbonyl carbons. There are likely multiple D-amiino acids. N-terminally motified, S2, T6 dehydrated, Y8 is O-glycosylated, S10, S12, S14, and S16 became D-alanines
Bio-Activity Profile
Antimicrobial
S. simulans 22
0.11 μM
MIC
RECORD: Rec_0396596
VERIFIED: YES
Provenance & Taxonomy
Streptomyces cacaoi [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Thioether bonds between S1 and C5, and T18 and C23. In addition, C23 is dehydrated to form a double bond between Calpha and carbonyl carbons. There are likely multiple D-amiino acids. N-terminally motified, S2, T6 dehydrated, Y8 is O-glycosylated, S10, S12, S14, and S16 became D-alanines
Bio-Activity Profile
Antimicrobial
M. tuberculosis H37Ra
13.6 μM
MIC
RECORD: Rec_0426119
VERIFIED: YES
Provenance & Taxonomy
Streptomyces cacaoi [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Thioether bonds between S1 and C5, and T18 and C23. In addition, C23 is dehydrated to form a double bond between Calpha and carbonyl carbons. There are likely multiple D-amiino acids. N-terminally motified, S2, T6 dehydrated, Y8 is O-glycosylated, S10, S12, S14, and S16 became D-alanines
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus SG511 or SG511 DapR or clinical isolate MRSA MB5393
0.22-13.6 μM
MIC