Peptide Database

Peptide NameSLAY-screened peptide P438

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H171N27O33S2

DescriptionStandard

        TLETRFYLFYTLDTMMSKHN
    

Molecular Weight2511.87 Da

Isoelectric Point (pI)6.42

Net Charge (pH 7.0)-0.51

Net Charge (pH 7.4) -0.76

Charge Density (pH 7.0) -0.0257

GRAVY Index-0.38

Hydrophobic Moment 0.38

Boman Index0.01

Instability Index62.71

Aliphatic Index 58.50

Aromaticity 0.2000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 992.12

LogP -7.28

H-bond Donors 36.0

H-bond Acceptors 36.0

Rotatable Bonds 81.0

Heavy Atoms 176.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0385359 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/