Peptide Database

Peptide NameccTP 6 (Derived from TP2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC89H149N35O19S6

DescriptionStandard

        GWCRCVCRRGICRCFCRK
    

Molecular Weight2205.75 Da

Isoelectric Point (pI)9.57

Net Charge (pH 7.0)5.70

Net Charge (pH 7.4) 5.41

Charge Density (pH 7.0) 0.3166

GRAVY Index-0.09

Hydrophobic Moment 0.64

Boman Index-0.39

Instability Index34.50

Aliphatic Index 37.78

Aromaticity 0.1111

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 909.33

LogP -9.40

H-bond Donors 42.0

H-bond Acceptors 31.0

Rotatable Bonds 72.0

Heavy Atoms 149.0

Ring Count 3.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0396354 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 5-14; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

Targethuman red blood cells

PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/

RECORD: Rec_0401230 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 5-14; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetCandida kefyr

Activity1.1 μM

MethodMIC

PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/

RECORD: Rec_0414927 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 5-14; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetPrimula vulgaris

Activity17.0 μM

MethodMIC

PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/

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