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MYP_078752
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Basic Information
[Pro3,DLeu9,Nle10]TL-GGC-CHOL
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
16 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FVPWFSKFLXRILGGC
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0361213 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
PEG4-Cholesterol-NH2
The 'X' at position 10 is norleucine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0378265 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
PEG4-Cholesterol-NH2
The 'X' at position 10 is norleucine
Bio-Activity Profile
Antimicrobial Antiviral
HSV-1:inhibition of HSV-1 replication in Vero cells
9.54 μM
IC50
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0386220 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Nle, C- terminal: PEG4-cholesterol-NH2, small case letters are D amino acids at 10; Nle, C- terminal: PEG4-cholesterol-NH2, small case letters are D amino acids
Bio-Activity Profile
Antimicrobial Antifungal
Measles virus
40.89 μM
IC50
PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
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