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MYP_078745
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Basic Information
Brevinin-1Ja (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
21 amino acids
C103H179N25O24
Standard
Sequence
FLGSLIGAAIPAIKQLLGLKK
Physicochemical Analysis
2151.68 Da
10.30
2.76
2.55
0.1313
1.04
0.43
0.41
16.45
162.86
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
777.91
-3.19
26.0
27.0
74.0
152.0
2.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0061348 VERIFIED: YES
Provenance & Taxonomy
Rana japonica [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
119 μM
MIC
PMID18558801 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18558801/
RECORD: Rec_0063685 VERIFIED: YES
Provenance & Taxonomy
Rana japonica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
15 μM
MIC
RECORD: Rec_0107267 VERIFIED: YES
Provenance & Taxonomy
Rana japonica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0144082 VERIFIED: YES
Provenance & Taxonomy
Rana japonica [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
15 μM
MIC
PMID18558801 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18558801/
RECORD: Rec_0162725 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
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