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MYP_078722
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Basic Information
CL58.d
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
18 amino acids
C94H143N21O21S
Standard
Sequence
MANAGLQLLGFILAFLGW
Physicochemical Analysis
1935.33 Da
5.28
-0.50
-0.72
-0.0278
1.52
0.34
0.68
51.97
146.67
0.1667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
659.99
-1.03
22.0
22.0
61.0
137.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0325178 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
Hepatitis C virus (HCV) | Huh7.5.1 cells
2.1±0.5 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA human claudin-1-derived peptide inhibits hepatitis C virus entry. | Si Y, Liu S, Liu X, Jacobs JL, Cheng M, Niu Y, Jin Q, Wang T, Yang W. | Hepatology. 2012 Aug;56(2):507-15. | DOI:10.1002/hep.25685 | PMID:22378192 PMID22378192 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22378192/
RECORD: Rec_0352733 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 77.8%, E 0.0%, T 5.6%, C 16.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0363721 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Protein-derived synthetic peptide
9606
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
Hepatitis C virus (HCV) | Huh7.5.1 cells
1.8±0.4 μM
IC50
PaperA human claudin-1-derived peptide inhibits hepatitis C virus entry. | Si Y, Liu S, Liu X, Jacobs JL, Cheng M, Niu Y, Jin Q, Wang T, Yang W. | Hepatology. 2012 Aug;56(2):507-15. | DOI:10.1002/hep.25685 | PMID:22378192 PMID22378192 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22378192/
RECORD: Rec_0404797 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Claudin-derived
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Hepatitis C virus (Virus entry); Huh7.5.1
2.1 μM
Pseudoviral particle infection assay
PaperA human claudin-1-derived peptide inhibits hepatitis C virus entry. | Si Y, Liu S, Liu X, Jacobs JL, Cheng M, Niu Y, Jin Q, Wang T, Yang W. | Hepatology. 2012 | PMID:22378192 PMID22378192 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22378192/
RECORD: Rec_0419654 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Huh7.5.1 cells
~200 μM
CC50
PaperPubMed PMID: 22378192 PMID22378192 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22378192/
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