Peptide Database

Peptide NameNatriuretic peptide PpNP-a

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC141H227N43O48S3

DescriptionStandard

        SGSKTANIGDGCFGVPIDHIGSTSGMGCGSPRPKP
    

Molecular Weight3388.77 Da

Isoelectric Point (pI)7.81

Net Charge (pH 7.0)0.53

Net Charge (pH 7.4) 0.24

Charge Density (pH 7.0) 0.0151

GRAVY Index-0.34

Hydrophobic Moment 0.34

Boman Index0.09

Instability Index54.07

Aliphatic Index 44.57

Aromaticity 0.0286

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1419.48

LogP -22.34

H-bond Donors 50.0

H-bond Acceptors 53.0

Rotatable Bonds 106.0

Heavy Atoms 235.0

Ring Count 6.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0125296 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudechis porphyriacus [Animal]

FamilyNatriuretic peptide PpNP

Tax ID8671

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour