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MYP_078590
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Basic Information
Defensin D1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
50 amino acids
C232H355N69O70S8
Standard
Sequence
KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKPPAHRCICYYEC
Physicochemical Analysis
5487.24 Da
8.48
2.86
2.42
0.0571
-0.60
0.37
-0.09
28.32
35.20
0.1000
9970.00
10470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2230.21
-26.90
85.0
83.0
176.0
379.0
11.0
52.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0180654 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Fusarium culmorum (IC50=6.9 μg/ml) and Botrytis cinerea
27.4 μg/mL
IC50
PaperPubMed PMID: 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0187900 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Plant]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Fusarium oxysporum
9.5 μg/mL
IC50
PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0202616 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antifungal
Aspergillus niger
3.5 μg/mL
IC50
PaperPubMed PMID 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0221673 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Plant]
Defensin
Structure & Mods
linear disulfide-stabilized peptide [Linear]
canonical L-amino-acid peptide [L]
3-50, 14-35, 20-44, 24-46
Bio-Activity Profile
Antimicrobial Antifungal
Aspergillus niger
3.5 μg/mL
IC50
RECORD: Rec_0227529 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
NOTE: Inhibition zone
PaperPubMed PMID: 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
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