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MYP_078550
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Basic Information
DFT563
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C68H127N15O16
Standard
Sequence
GLSLLLSLKLKLL
Physicochemical Analysis
1410.83 Da
10.00
1.76
1.55
0.1352
1.58
0.18
0.43
-16.89
240.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
505.02
-0.54
18.0
18.0
51.0
99.0
0.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0034336 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is poorly similar (92.31%) to DFT503 . L: 62%. Chemical modification: C-terminal amidation
Bio-Activity Profile
Antimicrobial
P-aeruginosa PAO1
>25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0064291 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is poorly similar (92.31%) to DFT503 . L: 62%. Chemical modification: C-terminal amidation
Bio-Activity Profile
Antimicrobial
E-coli ATCC 25922
>25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0072688 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus USA 300
6.2 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0116472 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO1
25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0118355 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
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