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MYP_078440
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Basic Information
Big defensin (crabs, Arthropods, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
79 amino acids
C380H582N114O106S6
Standard
Sequence
NPLIPAIYIGATVGPSVWAYLVALVGAAAVTAANIRRASSDNHSCAGNRGWCRSKCFRHEYVDTYYSAVCGRYFCCRSR
Physicochemical Analysis
8635.78 Da
9.27
5.87
5.47
0.0743
0.07
0.44
0.06
38.34
75.44
0.1266
19940.00
20315.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3524.85
-38.55
135.0
120.0
266.0
606.0
17.0
82.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0197607 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
big defensin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
45-75; 52-70; 56-76
Bio-Activity Profile
Antimicrobial big defensin family Antifungal Host defense Defensin-like
PaperPDB 2RNG structural record; NMR; chain A; residues 1-79
RECORD: Rec_0208898 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
10 μg/mL
IC50
PaperPubMed PMID: 8586631 | PubMed PMID: 18785751 PMID8586631;18785751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8586631/
RECORD: Rec_0237357 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Defensin
6853
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperJ Biochem. 1995 May;117(5):1131-7. | http://www.ncbi.nlm.nih.gov/pubmed/8586631 PMID8586631 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8586631/
RECORD: Rec_0384964 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
minnesota R595
1.3 μg/mL
IC50
PaperPubMed PMID: 8586631 | PubMed PMID: 18785751 PMID8586631;18785751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8586631/
RECORD: Rec_0389413 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Note: Washed with a phosphate buffered saline (PBS, pH 7.0)
PaperPubMed PMID: 8586631 | PubMed PMID: 18785751 PMID8586631;18785751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8586631/
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