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MYP_078440
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Basic Information
Big defensin (crabs, Arthropods, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
79 amino acids
C380H582N114O106S6
Standard
Sequence
NPLIPAIYIGATVGPSVWAYLVALVGAAAVTAANIRRASSDNHSCAGNRGWCRSKCFRHEYVDTYYSAVCGRYFCCRSR
Physicochemical Analysis
8635.78 Da
9.27
5.87
5.47
0.0743
0.07
0.44
0.06
38.34
75.44
0.1266
19940.00
20315.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3524.85
-38.55
135.0
120.0
266.0
606.0
17.0
82.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026699 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli 09:K39
5 μg/mL
IC50
PaperPubMed PMID: 8586631 | PubMed PMID: 18785751 PMID8586631;18785751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8586631/
RECORD: Rec_0056769 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
PMID8586631 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8586631/
RECORD: Rec_0097932 VERIFIED: NO
Provenance & Taxonomy
Arthropoda [Animal]
6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0153953 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperPubMed PMID: 8586631 | PubMed PMID: 18785751 PMID8586631;18785751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8586631/
RECORD: Rec_0181290 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Gram+
PaperA novel big defensin identified in horseshoe crab hemocytes: isolation, amino acid sequence, and antibacterial activity.
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