Peptide Database

Peptide Namespantide I

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC75H107N19O14

DescriptionStandard

        RPKPQQWFWLL
    

Molecular Weight1498.77 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.1599

GRAVY Index-0.91

Hydrophobic Moment 0.20

Boman Index-0.05

Instability Index65.98

Aliphatic Index 70.91

Aromaticity 0.2727

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 542.42

LogP -0.04

H-bond Donors 18.0

H-bond Acceptors 16.0

Rotatable Bonds 43.0

Heavy Atoms 108.0

Ring Count 7.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0013795 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsAmidation of C terminal leucine residue

Bio-Activity Profile

Function

Receptor antagonist Signaling peptide

TargetNK1 receptor (Rat); NK1 receptor (Guinea pig); NK1 receptor (Rabbit)

Activity2000 nM

MethodIC50